1.Ya-Wen Lin, Ming-De Yan, Yu-Lueng Shih, Chung-Bao Hsieh. The basal body gene, RPGRIP1L, is a candidate tumour suppressor gene in human hepatocellular carcinoma. European J Cancer 2009: 2041-2049. 4.819
2.Hsieh SY, Huang SF, Yu MC, Yeh TS, Chen TC, Lin YJ, Chang CJ, Sung CM, Lee YL, Hsu CY. Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinog. 2010 May;49(5):476-87. 4.770
3. Liang TJ, Mok KT, Liu SI, Huang SF, ChouNH, Tsai CC, Chen IS, Yeh MH, Chen YC, Wang BW. Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma. J Am Coll Surg. 2010 Nov;211(5):580-6. Epub 2010 Sep 20. 4.454
4. Hsieh SY, He JR, Hsu CY, Chen WJ, Bera R, Lin KY, Shih TC, Yu MC, Lin YJ, Chang CJ, Weng WH, Huang SF. Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma. Hepatology. 2011 Feb;53(2):504-16 11.190
5. Tao Y, Ruan J, Yeh SH, et al. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12042-7. Epub 2011 Jul 5. 9.809
6. Chen MH, Yang WL, Lin KT, Liu CH, Liu YW, Huang KW, Chang PM, Lai JM, Hsu CN, Chao KM, Kao CY, Huang CY. Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma. PLoS One. 2011;6(11):e27186. doi: 10.1371/journal.pone.0027186. Epub 2011 Nov 7. 3.534
7. Chen JS, Su IJ, Leu YW, Young KC, Sun HS. Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer. Int J Cancer. 2012;130:1302-1313. 5.007
8. Yen, Chia-Hung, Lu, Yao-Cheng, Li, Chung-Hsien, Lee, Cheng-Ming, Chen, Chia-Yen, Cheng, Ming-Yuan, Shiu-Feng Huang, Chen, Kuen-Feng, Cheng, Ann-Lii, Liao, Li-Ying, Wu-Lee, Yan-Hwa, Chen, Yi-Ming. Functional characterization of Glycine N-methyltransferase and its interactive protein-DEPDC6/DEPTOR in hepatocellular carcinoma. Molecular Medicine 2012 Mar 30;18(3):286-96. 4.824
9. Yi-Jen Liao, Tzu-Lang Chen, Tzong-Shyuan Lee, Hsiang-An Wang, Chung-Kwe Wang, Li-Ying Liao, Ren-Shyan Liu, Shiu-Feng Huang, and Yi-Ming Arthur Chen. Glycine N-methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis. Molecular Medicine 2012 May 9;18(1):412-22, Epub 2011, Dec. 4.824
10. Lu JW, Hsia Y, Yang WY, Lin YI, Li CC, Tsai TF, Chang KW, Shieh GS, Tsai SF, Wang HD, Yuh CH. Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model. Carcinogenesis. 2012 Jan;33(1):209-19. doi: 10.1093/carcin/bgr224. Epub 2011 Oct 21. 5.266
11. Tzu-Ching Kuo, Ph.D.; Pu-Yuan Chang, Ph.D.; Shiu-Feng Huang, MD, Ph.D.; Chen-Kung Chou, Ph.D.; Chuck C.-K. Chao, Ph.D. Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53. Biochemical Pharmacology 2012;83:758-768. 4.650
12. Tsao CM, Yan MD, Shih YL, Yu PN, Kuo CC, Lin WC, Li HJ, Lin YW. SOX1 functions as a tumor suppressor by antagonizing the WNT/β-catenin signaling pathway in hepatocellular carcinoma. Hepatology. 2012 Dec;56(6):2277-87. doi: 10.1002/hep.25933. 11.190
13. Wang SH, Yeh SH, Lin WH, Yeh KH, Yuan Q, XiaNS, Chen DS, Chen PJ. Estrogen receptor α represses transcription of HBV genes via interaction with hepatocyte nuclear factor 4α. Gastroenterology. 2012 Apr;142(4):989-998.e4. Epub 2012 Jan 10. 13.926
14. Lin ZS, Chu HC, Yen YC, Lewis BC, Chen YW. Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLoS One. 2012;7(8):e43593. doi: 10.1371/journal.pone.0043593. Epub 2012 Aug 24. 3.534
15. Chen PJ,Yeh SH, Liu WH, Lin CC, Huang HC, Chen CL, Chen DS, Chen PJ. Androgen pathway stimulates microRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis. Hepatology. 2012 Aug;56(2):632-43. doi: 10.1002/hep.25695. Epub 2012 Jun 11. 11.190
16. Shih YL, Hsieh CB, Yan MD, Tsao CM, Hsieh TY, Liu CH, Lin YW. Frequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2013 Mar;28(3):551-9 3.627
17. Lo SJ, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang SF, Chang CJ, Lin YJ, Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells.Hepatology. 2013 May;57(5):1893-905. doi: 10.1002/hep.26209. Epub 2013 Apr 1. 11.190
18. Huang YH, Lin YH, Chi HC, Liao CH, Liao CJ, Wu SM, Chen CY, Tseng YH, Tsai CY, Lin SY, Hung YT, Wang CJ, Lin CD, Lin KH. Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma. Cancer Res. 2013 Apr 15;73(8):2505-17. doi: 10.1158/0008-5472.CAN-12-2218. Epub 2013 Feb 26. 9.284
19. Charles Balabaud, Wesal R. Al-Rabih, Pei-Jer Chen, Kimberley Evason, Linda Ferrell, Juan C. Hernandez-Prera, Shiu-Feng Huang, Thomas Longerich, Young Nyun Park, Alberto Quaglia, Peter Schirmacher, Christine Sempoux, Swan N. Thung, Michael Torbenson, Aileen Wee, Matthew M. Yeh, Shiou-Hwei Yeh, Brigitte Le Bail, Jessica Zucman-Rossi, and Paulette Bioulac-Sage. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. Int J Hepatol vol. 2013, Article ID 268625, 12 pages, 2013. 非SCI
20. Lin IY, Yen CH, Liao YJ, Lin SE, Ma HP, Chan YJ, Chen YM. Identification of FKBP11 as a biomarker for hepatocellular carcinoma.Anticancer Res. 2013 Jun;33(6):2763-9. 1.872
21. Chen MH, Jan YH, Chang PM, Chuang YJ, Yeh YC, Lei HJ, Hsiao M, Huang SF, Huang CY, Chau GY. Expression of GOLM1 Correlates with Prognosis in Human Hepatocellular Carcinoma. Ann Surg Oncol. 2013;20 Suppl 3:S616-24.3.943
22. Yang-Hsiang Lin, Chia-Jung Liao, Ya-Hui Huang, Meng-Han Wu, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Tzu-I, Wu, Ming-Ming Tsai, Crystal D. Lin, and K-H Lin (corresponding author) Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells. Oncogene 2013; 32 (38), 4509-4518. 8.559
23. Chen JS, Hung WS, Chan HH, Tsai SJ, Sun HS. In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 2013 Feb 15;29(4):420-7. 4.621
24. Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, Lee YS, Yen TC, Hsieh SY. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol. 2012 Sep;57(3):584-91. 10.401
25. Liao YJ, Lin MW, Yen CH, Lin YT, Wang CK, Huang SF, Chen KH, Yang CP, Chen TL, Hou MF, Arthur Chen YM. Characterization of Niemann-Pick Type C2 protein expression in multiple cancers using a novel NPC2 monoclonal antibody.PLoS One. 2013 Oct 17;8(10):e77586. doi: 10.1371/journal.pone.0077586. eCollection 2013. 3.234 (2014 JCR Science Edition)
26. Hsei-Wei Wang, Tsung-Han Hsieh, SSu-Yi Huang, Gar-Yang Chau, Chien-Yi Tung, Chien-Wei Su and Jaw-Ching Wu. Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC. BMC Genomics 2013, 14:736 4.041
27. Liu WH, Chen CH, Yeh KH, Li CL, Wu YJ, Chen DS, Chen PJ, Yeh SH. ADAR2-Mediated Editing of miR-214 and miR-122 Precursor and Antisense RNA Transcripts in Liver Cancers. PLoS One. 2013 Dec 27;8(12):e81922. 3.534
28. Lin KT, Shann YJ, Chau GY, Hsu CN, Huang CY. Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing. Oncogene. 2014;33(39):4786-94.doi: 10.1038/onc.2013.424. [Epub ahead of print] 8.559
29. Lee MH, Yang HI, Lu SN, Jen CL, You SL, Wang LY, L'italien G, Chen CJ, Yuan Y; for the REVEAL-HCV Study Group. Hepatitis C Virus Genotype 1b Increases Cumulative Lifetime Risk of Hepatocellular Carcinoma. Int J Cancer. 2014;135(5):1119-26 doi: 10.1002/ijc.28753. [Epub ahead of print] 5.007
30. Lan SH, Wu SY, Zuchini R, Lin XZ, Su IJ, Tsai TF, Lin YJ, Wu CT, Liu HS. Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of miR-224. Hepatology.2014 Feb;59(2):505-17. 11.190
31.Ya-Wen Lin, Yu-Lueng Shih, Gi-Shih Lien, Fat-Moon Suk, Chung-Bao Hsieh, and Ming-De Yan. Promoter Methylation of SFRP3 Is Frequent in Hepatocellular Carcinoma. Disease Markers, Volume 2014, Article ID 351863, 10 pages (in press) 2.174
32. Bera R, Chiou CY, Yu MC, Peng JM, He CR, Hsu CY, Huang HL, Ho UY, Lin SM, Lin YJ, Hsieh SY. Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. Hepatology. 2014Jun;59(6):2238-50. doi: 10.1002/hep.27030. [Epub ahead of print] 11.190
33.Chang SW, Fann CS, Su WH, Wang YC, Weng CC, Yu CJ, Hsu CL, Hsieh AR, Chien RN, Chu CM, Tai DI. A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. PLoS One. 2014 Jun 18;9(6):e99724. doi: 10.1371/journal.pone.0099724. eCollection 2014. 3.534
34. Su JC, Tseng PH, Wu SH, Hsu CY, Tai WT, Li YS, Chen IT, Liu CY, Chen KF, Shiau CW. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. Neoplasia. 2014 Jul;16(7):595-605. doi: 10.1016/j.neo.2014.06.005. Epub 2014 Jul 18. 5.398
35. Kuo CC, Lin CY, Shih YL, Hsieh CB, Lin PY, Guan SB, Hsieh MS, Lai HC, Chen CJ, Lin YW. Frequent methylation of HOXA9 gene in tumor tissues and plasma samples from human hepatocellular carcinomas. Clin Chem Lab Med. 2014 Aug 1;52(8):1235-45 2.955
36.Li CL, Yeh KH, Liu WH, Chen CL, Chen DS, Chen PJ, Yeh SH. Elevated p53 promotes the processing of miR-18ato decrease estrogen receptor-α in female hepatocellular carcinoma. Int J Cancer. 2015 Feb 15;136(4):761-70.5.007
39. Kuo CC, Shih YL, Su HY, Yan MD, Hsieh CB, Liu CY, Huang WT, Yu MH, Lin YW. Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma. World J Gastroenterol. 2015 Apr 7;21(13):3960-9. doi: 10.3748/wjg.v21.i13.3960. 2.433
40. Chung IH, Chen CY, Lin YH, Chi HC, Huang YH, Tai PJ, Liao CJ, Tsai CY, Lin SL, Wu MH, Chen CY, Lin KH. Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer. Oncotarget. 2015 Jun 20;6(17):15050-15064. 6.627
41. Shih YT, Wang MC, Zhou J, Peng HH, Lee DY, Chiu JJ. Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte chemotactic protein-1 induction of microRNA-21. Gut2015 Jul;64(7):1132-1147.13.319
42. Ciou SC, Chou YT, Liu YL, Nieh YC, Lu JW, Huang SF, Chou YT, Cheng LH, Lo JF, Chen MJ, Yang MC, Yuh CH, Wang HD. Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling. Int J Cancer. 2015 Jul 1;137(1):104-15. doi: 10.1002/ijc.29361. Epub 2014 Dec 12. 5.007
43. Ou DL, Shyue SK, Lin LI, Feng ZR,Liou JY, Fan HH, Lee BS, Hsu C, Cheng AL. Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma. Oncotarget. 2015 Jun 29. [Epub ahead of print] 6.359 (2014 JCR Science Edition)
44. Liao YJ, Fang CC, Yen CH, Hsu SM, Wang CK, Huang SF, Liang YC, Lin YY, Chu YT, Arthur Chen YM. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications.Int J Cancer. 2015 Sep;137(6):1341-51. doi: 10.1002/ijc.29507. Epub 2015 Mar 24.5.085 (2014 JCR Science Edition)
45.Mei-Hsuan Lee, Hwai-I Yang, Sheng-Nan Lu, Yu-Ju Lin, Chin-Lan Jen, Kang-Hsuan Wong, Soa-Yu Chan, Liang-Chun Chen, Li-Yu Wang, Gilbert L’Italien, Yong Yuan & Chien-Jen Chen. Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma Risk. Sci Rep. 2015 Nov 25;5:17030. doi: 10.1038/srep17030. 5.578
47. Hu HH, Liu J, Lin YL, Luo WS, Chu YJ, Chang CL, Jen CL, Lee MH, Lu SN, Wang LY, You SL,Yang HI, Chen CJ; REVEAL-HBV Study Group. The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B. Gut. 2015 Dec 7. pii: gutjnl-2015-310686. doi: 10.1136/gutjnl-2015-310686. [Epub ahead of print] 14.921
48. Shiu-Feng Huang, Hong-Dar Isaac Wu, Ya-Ting Chen, Saravana R. K. Murthy, Yu-Ting Chiu, Yu-Chang, Il-Chi Chang, Xuyu Yang, and Y. Peng Loh. Carboxypeptidase E is a prediction marker for tumor recurrence in the early stage hepatocellular carcinoma. Tumor Biology 2016, Jan. 23, published online. Doi: 10.1007/s13277-016-4814-7. 3.611
49. Il-Chi Chang, PhD., Shiu-Feng Huang, MD.,PhD.,(corresponding author) Pei-Jer Chen, MD.,PhD., Chi-Ling Chen, PhD.,4Chao-Long Chen, MD., Cheng-Chung Wu, MD., Cheng-Chung Tsai, MD., Po-Huang Lee, MD., Miin-Fu Chen, MD.,Chuan-Mo Lee, MD., Hsien-Chung Yu, MD., Gin-Ho Lo, MD., Chau-Ting Yeh, MD.,PhD., Chih-Chen Hong, PhD., Hock-Liew Eng, MD., John Wang, MD., Hui-Hwa Tseng, MD., Cheng-Hsiang Hsiao, MD., Hong-Dar Isaac Wu, PhD., Tseng-Chang Yen, PhD., Yun-Fan Liaw MD. The hepatitis viral status in patients with hepatocellular carcinoma – a study of 3843 patients from Taiwan Liver Cancer Network. Medicine 2016 Apr;95(15):e3284.5.723 (ranking: 9.7%)
50. Yu-Lueng Shih, Chih-Chi Kuo, Ming-De Yan, Ya-Wen Lin, Chung-Bao Hsieh, and Tsai-Yuan Hsieh. Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma.Clin Epigenetics. 2016 Apr 22;8:41. doi: 10.1186/s13148-016-0208-3. eCollection 2016. 4.543
51. Liu J, Yang HI, Lee MH, Jen CL, Hu HH, Lu SN, Wang LY, You SL, Huang YT, Chen CJ. Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):693-9. doi: 10.1158/1055-9965.EPI-15-0961. Epub 2016 Jan 31. 3.622
52. Lin YF, Li LH, Lin CH, Tsou MH, Chuang MT, Wu KM, Liao TL, Li JC, Wang WJ, Tomita A, Tomita B, Huang SF, Tsai SF. Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma. PLoS Genet. 2016 May 20;12(5):e1006051. doi: 10.1371/journal.pgen.1006051. eCollection 2016. 6.1
53. Hao-Kang Li, Ru-Tsun Mai, Hsien-Da Huang, Chih-Hung Chou, Yi-An Chang, Yao-Wen Chang, Li-Ru You, Chun-Ming Chen, and Yan-Hwa Wu Lee. DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma.Sci Rep. 2016 Jun 27;6:28637. doi: 10.1038/srep28637. 5.578
56.Yi-Hsin Tseng, Ya-Hui Huang, Tzu-Kang Lin, Sheng-Ming Wu, Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Wei-Chun Chang, Ya-Ting Chang, Wei-Jan Chen, and Kwang-Huei Lin. Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci Rep. 2016 Dec 9;6:38756. doi: 10.1038/srep38756.5.228
57. Kuo TC, Chen CK, Hua KT, Yu P, Lee WJ, Chen MW, Jeng YM, Chien MH, Kuo KT, Hsiao M, Kuo ML. Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells. Cancer Lett. 2016 Dec 28;383(2):282-294. doi: 10.1016/j.canlet.2016.10.012. Epub 2016 Oct 8. 5.992
58. Wu SM, Lin SL, Lee KY, Chuang HC, Feng PH, Cheng WL, Liao CJ, Chi HC, Lin YH, Tsai CY, Chen WJ, Yeh CT, Lin KH. Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression. Int J Cancer. 2017 Apr 1;140(7):1581-1596. doi: 10.1002/ijc.30559. Epub 2017 Jan 19.7.36
59. Li CH, Yen CH, Chen YF, Lee KJ, Fang CC, Zhang X, Lai CC1, Huang SF, Lin HK, Arthur Chen YM. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Int J Cancer. 2017 May 15;140(10):2284-2297. doi: 10.1002/ijc.30652. 7.36
60. Yen CH, Lai CC, Liao CC, Wang SF, Liao YJ, Tung CY, Hung JH, Huang SF, Chen YA. Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development.Sci Rep. 2017 Jun 8;7(1):3052. doi: 10.1038/s41598-017-03164-3. 4.259
61. Hua KT, Liu YF, Hsu CL, Cheng TY, Yang CY, Chang JS, Lee WJ, Hsiao M, Juan HF, Chien MH, Yang SF. 3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma.Sci Rep.2017 Jun 30;7(1):4466. doi: 10.1038/s41598-017-04732-3.4.259
62. Wu MS, Wang CH, Tseng FC, Yang HJ, Lo YC, Kuo YP, Tsai DJ, Tsai WT, Yu GY. Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma.Infect Agent Cancer. 2017 Jul 26;12:42. doi: 10.1186/s13027-017-0152-7. eCollection 2017. 2.123
63. Kuo HH, Lin RJ, Hung JT, Hsieh CB, Hung TH, Lo FY, Ho MY, Yeh CT, Huang YL, Yu J, Yu AL. High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma. Sci Rep. 2017 Sep 7;7(1):10750. doi: 10.1038/s41598-017-11136-w. 4.259
64. Yeh HW, Lee SS, Chang CY, Hu CM, Jou YS. Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis. Oncotarget. 2017 Sep 8;8(44):77734-77751. doi: 10.18632/oncotarget.20774. eCollection 2017 Sep 29. 5.168
65.Chi HC, Chen SL, Lin SL, Tsai CY, Chuang WY, Lin YH, Huang YH, Tsai YH, Tsai MM, Yeh CT, Lin KH. Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene. 2017 Sep 14;36(37):5274-5284. doi:10.1038/onc.2017.136.Epub 2017 May 15. 6.854
66. Lee MH, Huang YH, Chen HY, Khor CS, Chang YH, Lin YJ, Jen CL, Lu SN, Yang HI, Nishida N, Sugiyama M, Mizokami M, Yuan Y, L'Italien G, Tokunaga K, Chen CJ; REVEAL-HCV cohort. Human Leukocyte Antigen Variants and Risk of Hepatocellular Carcinoma Modified by HCV Genotypes: A Genome-wide Association Study. Hepatology. 2017 Sep 16. doi: 10.1002/hep.29531. [Epub ahead of print] 13.246
67. Lin YY, Yu MW, Lin SM, Lee SD, Chen CL, Chen DS, Chen PJ. Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma. Cancer. 2017 Oct 15;123(20):3966-3976. doi: 10.1002/cncr.30851. Epub 2017 Jun 29. 6.072
68. Huang PS, Lin YH, Chi HC, Chen PY, Huang YH, Yeh CT, Wang CS, Lin KH. Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214.Sci Rep. 2017 Nov 1;7(1):14868. doi: 10.1038/s41598-017-14864-1. 4.259
69. Lin SL, Wu SM, Chung IH, Lin YH, Chen CY, Chi HC, Lin TK, Yeh CT, Lin KH. Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer. Neoplasia. 2018 Jan;20(1):57-68. doi: 10.1016/j.neo.2017.10.007. Epub 2017 Nov 29. 5.006
70. Lin YH, Wu MH, Huang YH, Yeh CT, Cheng ML, Chi HC, Tsai CY, Chung IH, Chen CY, Lin KH. Taurine up-regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma. Hepatology. 2018 Jan;67(1):188-203. doi: 10.1002/hep.29462. Epub 2017 Nov 15. 13.246
71. Lin KT, Ma WK, Scharner J, Liu YR, Krainer AR. A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma. Genome Res. 2018 Feb 15. doi: 10.1101/gr.227181.117. 11.922
72.Lee MH*, Huang YH, Chen HY, Khor C SS, Chang YH, Lin YJ, Jen CL, Lu SN, Yang HI, Nishida N, Sugiyama M, Mizokami M, Yuan Y, L’Italien G, Tokunaga K, Chen CJ. Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by HCV genotypes: a genome-wide association study. Hepatology, 2018; 67 (2): 651-661 (SCI, IF=14.1)
73.Shiu-Feng Huang, Il-Chi Chang, Chih-Chen Hong, Tseng-Chang Yen, Chao-Long Chen, Cheng-Chung Wu, Cheng-Chung Tsai, Ming-Chih Ho, Wei-Chen Lee, Hsien-Chung Yu, Ying-Ying Shen, Hock-Liew Eng, John Wang, Hui-Hwa Tseng, Yung-Ming Jeng, Chau-Ting Yeh, Chi-Ling Chen, Pei-Jer Chen, Yun-Fan Liaw. Metabolic risk factors are associated with non-hepatitis B non-hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B. Hepatol Commun. 2018 Apr 18;2(6):747-759. doi: 10.1002/hep4.1182. eCollection 2018 Jun.
74. Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology. 2018 Jun;67(6):2226-2243. doi: 10.1002/hep.29678. Epub 2018 Apr 19. 14.079
75. Wu SY, Lan SH, Wu SR, Chiu YC, Lin XZ, Su IJ, Tsai TF, Yen CJ, Lu TH, Liang FW, Li CY, Su HJ, Su CL, Liu HS. Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system. Hepatology. 2018 Jul;68(1):141-154. doi: 10.1002/hep.29781. Epub 2018 Mar 23.14.079
76. Hung JH, Li CH, Yeh CH, Huang PC, Fang CC, Chen YF, Lee KJ, Chou CH, Cheng HY, Huang HD, Chen M, Tsai TF, Lin AM, Yen CH, Tsou AP, Tyan YC, Chen YA. MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.Sci Rep. 2018 Aug 16;8(1):12284. doi: 10.1038/s41598-018-30682-5. 4.122
77. Chen CL, Tsai YS, Huang YH, Liang YJ, Sun YY, Su CW, Chau GY, Yeh YC, Chang YS, Hu JT, Wu JC. Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial-Mesenchymal Transition Regulators and Stemness Genes. Hepatol Commun. 2018 Sep 28;2(11):1392-1407. doi: 10.1002/hep4.1229. eCollection 2018 Nov.
78. Lai YS, Cheng CC, Lee MT, Chao WT, Lai YC, Hsu YH, Liu YH. The Prognostic Value of Cytokeratin and Sal-Like Protein 4 Expression in Hepatocellular Carcinoma and Intra-Hepatic Cholangiocarcinoma in Taiwan. Int J Med Sci. 2018 Nov 23;15(14):1746-1756. doi: 10.7150/ijms.28440. eCollection 2018.2.284
79. Kant R, Yen CH, Hung JH, Lu CK, Tung CY, Chang PC, Chen YH, Tyan YC, Chen YA. Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma. Sci Rep. 2019 Feb 13;9(1):1968. doi: 10.1038/s41598-018-37292-1. 4.122
80.Yang MH,, Yen CH, Chen YF, Fang CC, Li CH, Lee KJ, Lin YH, Weng CH, Liu TT, Huang SF, Teh BT, Chen YA. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. Sci Rep. 2019 Feb 22;9(1):2552. doi: 10.1038/s41598-018-36810-5. 4.122
81. Chen CY, Wu SM, Lin YH, Chi HC, Lin SL, Yeh CT, Chuang WY, Lin KH. Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer. Theranostics. 2019 Apr 13;9(8):2361-2379. doi: 10.7150/thno.29628. eCollection 2019. 8.063
82. Wu YJ, Ko BS, Liang SM, Lu YJ, Jan YJ, Jiang SS, Shyue SK, Chen L, Liou JY. ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma. Cell Death Dis. 2019 May 28;10(6):408. doi: 10.1038/s41419-019-1651-9. 5.959
83. Xuyu Yang, Hong Lou, Ya-Ting Chen, Shui-Feng Huang and Y. Peng Loh. A novel 40kDa N-terminal truncated Carboxypeptidase E splice variant: Cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers. Genes & Cancer, Advanced Publications 2019 Jul 15
84. Wang SY, Chen CL, Hu YC, Chi Y, Huang YH, Su CW, Jeng WJ, Liang YJ, Wu JC. High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger Patients. Cancers (Basel). 2019 Oct 13;11(10). pii: E1549. doi: 10.3390/cancers11101549. 6.162
85. Liu YC, Lu LF, Li CJ, Sun NK, Guo JY, Huang YH, Yeh CT, Chao CC. Hepatitis B virus X protein induces RHAMM-dependent motility in hepatocellular carcinoma cells via PI3K-Akt-Oct-1 signaling. Mol Cancer Res. 2019 Dec 2. pii: molcanres.0463.2019. doi: 10.1158/1541-7786.MCR-19-0463.4.63
86. Lin YH, Wu MH, Huang YH, Yeh CT, Lin KH. TUG1 is a Regulator of AFP and Serves as Prognostic Marker in Non-Hepatitis B Non-Hepatitis C Hepatocellular Carcinoma. Cells. 2020 Jan 21;9(2). pii: E262. doi: 10.3390/cells9020262. 5.216
87. Ho TC, Wang EY, Yeh KH, Jeng YM, Horng JH, Wu LL, Chen YT, Huang HC, Hsu CL, Chen PJ, Yeh SH, Chen DS. Complement C1q mediates the expansion of periportal hepatic progenitor cells in senescence-associated inflammatory liver. Proc Natl Acad Sci USA. 2020 Mar 5; 117(12). pii: 201918028. doi: 10.1073/pnas.1918028117. 9.412
88. Huang PS, Lin YH, Chi HC, Tseng YH, Chen CY, Lin TK, Yeh CT, Lin KH. Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer. Cells. 2020 April 14; 9(4). pii: E961. doi: 10.3390/cells9040961. 5.216
89. Liu YC, Yeh CT, Lin KH. Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies Cells. 2020 May 26;9(6):1331.doi: 10.3390/cells9061331. 5.216
90. Lin SL, Lin YH, Chi HC, Lin TK, Chen WJ, Yeh CT, Lin KH. A Novel Long Non-Coding RNA-01488 Suppressed Metastasis and Tumorigenesis by Inducing miRNAs That Reduce Vimentin Expression and Ubiquitination of Cyclin E. Cells. 2020 June 20; 9(6). pii: E1504. doi: 10.3390/cells9061504. 5.216
91. Peng JM, Tseng RH, Shih TC, Hsieh SY.CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling. Cancer Lett. 2020 Oct 15;497:66-76. doi: 10.1016/j.canlet.2020.10.017. Online ahead of print.PMID: 33068700. 7.360
92.Peng JM, Lin SH, Yu MC, Hsieh SY. CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.J Clin Invest. 2021 Jan 4;131(1):e133525. doi: 10.1172/JCI133525.PMID: 33079727.13.393
93.Chen KY, Huang YH, Teo WH, Chang CW, Chen YS, Yeh YC, Lee CJ, Lo JF. Loss of Tid1/DNAJA3 Co-Chaperone Promotes Progression and Recurrence of Hepatocellular Carcinoma after Surgical Resection: A Novel Model to Stratify Risk of Recurrence. Cancers (Basel). 2021 Jan 4;13(1):138. doi: 10.3390/cancers13010138.PMID: 33406664.6.433
94. Ou DL, Chen CW, Hsu CL, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH, Hsu C. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages . J Immunother Cancer. 2021 Mar;9(3):e1001657. doi:10.1136/jitc -2020-001657.PMID:33753566. 10.252
95. Liu Z, Huang CJ, Huang YH, Pan MH, Lee MH, Yu KJ, Pfeiffer RM, Viard M, Yuki Y, Gao X, Carrington M, Chen CJ, Hildesheim A, Yang HI; REVEAL-HBV Study Group. HLA zygosity increases risk of hepatitis B virus-associated hepatocellular carcinoma. J Infect Dis. 2021 Apr 14:jiab207. doi: 10.1093/infdis/jiab207.5.802
96. Lin CC, Liu TW, Yeh ML, Tsai YS, Tsai PC, Huang CF, Huang JF, Chuang WL, Dai CY, Yu ML. Significant down-regulation of growth hormone receptor expression revealed as a new unfavorable prognostic factor in hepatitis C virus-related hepatocellular carcinoma. Clin Mol Hepatol. 2021 Apr;27(2):313-328. doi: 10.3350/cmh.2020.0247.6.074
97. Huang PS, Chang CC, Wang CS, Lin KH. Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer. Biomed J. 2021 Jun;44(3):272-284. doi: 10.1016/j.bj.2020.08.009.4.91
98. Lin YH, Wu MH, Liu YC, Lyu PC, Yeh CT, Lin KH. LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing. Oncogene. 2021 Jul;40(28):4675-4685. doi: 10.1038/s41388-021- 01905-3. Epub 2021 Jun 17. 9.867
99. Hsu CL, Ou DL, Bai LY, Chen CW, Lin L, Huang SF, Cheng AL, Jeng YM, Hsu C. Exploring Markers of Exhausted CD8 T Cells to Predict Response to Immune Checkpoint Inhibitor Therapy for Hepatocellular Carcinoma. Liver Cancer 2021 May 12;10:346–359 DOI: 10.1159/000515305 11.74
100. Huang LH, Hsieh TM, Huang CY, Liu YW, Wu SC, Chien PC, Hsieh CH. Disparity ofHepatocellular Carcinoma in Tumor Microenvironment-Related Genes and Infiltrating Immune Cells between Asian and Non-Asian Populations. Genes (Basel). 2021 Aug 20;12(8):1274. doi: 10.3390/genes120812744.339
101. Ko BS, Liang SM, Chang TC, Wu JY, Lee PH, Hsu YJ, Kuo CC, Liou JY, Wu KK.Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma. Cancers (Basel). 2021 Oct 22;13(21):5311. doi: 10.3390/cancers13215311.6.999
102. Wang LT, Liu KY, Chiou SS, Huang SK, Hsu SH, Wang SN. Phosphorylation of intestine-specific homeobox by ERK1 modulates oncogenic activity and sorafenib resistance. Cancer Lett. 2021 Nov 1;520:160-171. doi: 10.1016/j.canlet.2021.07.011.8.679
103.Wang Z, Budhu AS, Shen Y, Wong LL, Hernandez BY, Tiirikainen M, Ma X, Irwin ML, Lu L, Zhao H, Lim JK, Taddei T,
Mishra L, Pawlish K, Stroup A, Brown R, Nguyen MH, Koshiol J, Hernandez MO, Forgues M, Yang HI, Lee MH,
Huang YH, Iwasaki M, Goto A, Suzuki S, Matsuda K, Tanikawa C, Kamatani Y, Mann D, Guarnera M, Shetty K,
Thomas CE, Yuan JM, Khor CC, Koh WP, Risch H, Wang XW, Yu H. Genetic susceptibility to hepatocellular carcinoma in
chromosome 22q13.31, findings of a genome-wide association study. JGH Open. 2021 Nov 27;5(12):1363-1372. 4.029
104.Tseeleesuren D, Hsiao HH, Kant R, Huang YC, Tu HP, Lai CC, Huang SF, Yen CH. The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma. Medicina (Kaunas). 2022 Feb 1;58(2):212. 2.43
105.Lin MT, Chiu SY, Chang KC, Li WF, Yong CC, Liu YW, Wang JH, Kuo FY, Huang CC, Wang CC, Hsiao CC, Hu TH. Significant association between serum Wisteria floribunda agglutinin-positive Mac-2-binding protein and prognosis of hepatocellular carcinoma after surgical treatment. Am J Cancer Res. 2022 Feb 15;12(2):601-614. 6.166
106. Wei-Shan Chin, Shin-Chun Pan, Ching-Chun Huang, Pei-jer Chen, Yue Leon Guo. Exposure to Air Pollution and Survival in Follow-up after Hepatocellular Carcinoma. Liver Cancer 2022;11: 474-482. Doi:10.1159/000525346 12.430
107. Kuei-Min Chung, Ya-Ting Chen, Chih-Chen Hong, Il-Chi Chang, Si-Ying Lin, Li-Yu Liang, Yi-Rong Chen, Chau-Ting Yeh, Shiu-Feng Huang.. CA10 is associated with HBV-related hepatocarcinogenesis. Biochemistry and Biophysics Reports. 2022 Sep;31:Article number 101303. IF:2.6
112.Yu-Chin Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Po-Shuan Huang, Chia-Jung Liao, Yu-Syuan Liou, Chiao-Chun Lin, Chia-Jung Yu, Chau-Ting Yeh, Ya-Hui Huang, Kwang-Huei Lin. CRNDE acts as an epigenetic modulator of the p300/YY1 complex to promote HCC progression and therapeutic resistance. ClinEpigenetics. 2022 Aug 23;14(1):106. doi: 10.1186/s13148-022-01326-3 7.280
113.Kai-Wei Chen, Yu-Shan Chen, Pei-Jer Chen, Shiou-Hwei Yeh. Androgen receptor functions in pericentral hepatocytes to decrease gluconeogenesis and avoid hyperglycemia and obesity in male mice. Metabolism. 2022 Oct; 135:155269. doi: 10.1016/j.metabol.2022.155269. Epub 2022 Jul 29. 13.934
114.Lan-Ting Yuan, Yi-Chieh Yang, Hsiang-Lin Lee, Pei-Chun Shih, Li-Hsin Chen, Chih-Hsin Tang, Lun-Ching Chang, Hsiang-Ling Wang, Shun-Fa Yang, Ming-Hsien Chien. Genetic Polymorphisms of lncRNA LINC00673 as Predictors of Hepatocellular Carcinoma Progression in an Elderly Population. Int J Mol Sci. 2022 Oct 22;23(21):12737. doi: 10.3390/ijms232112737. 6.628
115. Kwong-Ming Kee, Chien-Hung Chen, Jui-Ting Hu, Yi-Hsiang Huang, Tsang-En Wang, Gar-Yang Chau, Kuo-Hsin Chen, Yao-Li Chen, Chih-Che Lin, Chien-Fu Hung, Shiu-Feng Huang, Tsang-Wu Liu, Hsiu-Ying Ku, Bing-Shen Huang, Yi-Pin Wang, Hui-Ping Tseng, Chun-Ju Chiang, Sheng-Nan Lu. Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019. Viruses 2023, 15, 126. https://doi.org/10.3390/v150101265.818
116. Chao-Jen Li, Hung-Wen Tsai, Yi-Li Chen, Chun-I Wang, Yang-Hsiang Lin, Pei-Ming Chu, Hsiang-Cheng Chi, Yi-Ching Huang, Cheng-Yi Chen. Cisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2023 Jan 30;10:123-138. doi:10.2147/JHC.S385238. eCollection 2023.6.38
117. Hung-Wen Tsai, Yi-Li Chen, Chun-I Wang, Ching-Chuan Hsieh, Yang-Hsiang Lin, Pei-Ming Chu, Yuh-Harn Wu, Yi-Ching Huang, Cheng-Yi Chen. Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma. Cancer Cell Int. 2023 Mar 10;23(1):42. doi: 10.1186/s12935-023-02879-w.6.435
118. Po-Shuan Huang, Ling-Yu Wang, Yi-Wen Wang, Ming-Ming Tsai, Tzu-Kang Lin, Chia-Jung Liao, Chau-Ting Yeh, Kwang-Huei Lin. Evaluation and Application of Drug Resistance by Biomarkers in the Clinical Treatment of Liver Cancer. Cells. 2023 Mar 10;12(6):869. doi: 10.3390/cells12060869. 7.677
119. Shih-Chung Huang, Chao-Cheng Huang, Chou-Yuan Ko, Cheng-Yi Huang, Ching-Han Liu, Yung-Kuo Lee, Tung-Yuan Chen, Chao-Wen Hsueh, Shiow-Jyu Tzou, Ming-Hong Tai, Tsung-Hui Hu, Ming-Chao Tsai, Wen-Chin Lee, Yu-Cheng Ho, Cheng-Chun Wu, Yi-Chen Chang, Jung-Jui Chang, Kai-Hsi Liu, Chiao-Ching Li, Zhi-Hong Wen, Chen-Lin Chang, Tian-Huei Chu. Slow skeletal muscle troponin T acts as a potential prognostic biomarker and therapeutic target for hepatocellular carcinoma. Gene. 2023 May 20;865:147331. doi: 10.1016/j.gene.2023.147331. Epub 2023 Mar 5. 3.913
120. Pei-Min Hsieh, Pojen Hsiao, Yaw-Sen Chen, Jen-Hao Yeh, Chao-Ming Hung, Hung-Yu Lin, Ching-Hou Ma, TaoQian Tang, Yu Wei Huang, Pin-Nan Cheng, Kun-Chou Hsieh, Kuang-Chun Hu, Ming-Jong Bair, Chih-Wen Lin. Clinical prognosis of surgical resection versus transarterial chemoembolization for single large hepatocellular carcinoma(≥5 cm): A propensity score matching analysis. Kaohsiung J Med Sci. 2023 Mar;39(3):302-310. doi: 10.1002/kjm2.12640. Epub 2023 Jan 10.2.996
122. Chiao-Ling Li, Chia-Lang Hsu, You-Yu Lin, Ming-Chih Ho, Ray-Heng Hu, Chi-Ling Chen, Tung-Ching Ho, Yung-Feng Lin, Shih-Feng Tsai, Sheng-Tai Tzeng, Chin-Fang Huang, Ya-Chun Wang, Shiou-Hwei Yeh, Pei-Jer Chen. HBV DNA Integration into Telomerase or MLL4 Genes and TERT Promoter Point Mutation as Three Independent Signatures in Subgrouping HBV-related HCC with Distinct Features. Liver cancer (in press) 13.8
123.Tsai-Hsien Hung, Yenlin Huang, Chau-Ting Yeh, Chun-Nan Yeh, John Yu, Chun-Cheng Lin, Shih-Pin Chiou, Pei-Yun Chiang, Jung-Tung Hung, Alice L Yu. High expression of embryonic stem cell marker SSEA3 confers poor prognosis and promotes epithelial mesenchymal transition in hepatocellular carcinoma. Biomed J. 2023 Jun 6:100612. doi: 10.1016/j.bj.2023.100612. Online ahead of print. 6.1
124.Hong Li, Chi-Ling Chian, Kwang Joo Kwak, Xinyu Wang, Sital Doddi, Lakshmi V Ramanathan, Sun M Cho, Ya-Chin Hou, Tai-Shan Cheng, Xiaokui Mo, Yueh-Shih Chang, Hui-Lan Chang, Weiming Cheng, Wei-Ni Tsai, Luong T H Nguyen, Junjie Pan, Yifan Ma, Xilal Y Rima, Jingjing Zhang, Eduardo Reategui, Yeh-Shiu Chu, Peter Mu-Hsin Chang, Pei-Hung Chang, Chi-Ying F Huang, Cheng-Hsu Wang, Yan-Shen Shan, Chung-Pin Li, Martin Fleisher, L James Lee. Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis. Adv Sci (Weinh). 2024 Jan 10:e2306373. doi: 10.1002/advs.202306373. Online ahead of print. 16.7
