Application List

No.

Name

Institution

Project Name

Application date

Patient No.

Approval date

070001

Yi-Ming Chen

AIDS Research Centre, National Yang-Ming University

Characterization of a GNMT gene knockout mouse model and application of the model in the hepatocarcinogenesis study.

20070501

20080415

20090205

90

30

140

20070819

20080513

20090219

070002

Shih-Feng Tsai

Division of molecular & genomic medicine, National Health Research Institutes

SNP analysis on HCC – correlation with genomic instability and gene expression

20070526

96

20070820

070003

Ya-Wen Lin

Department of Microbiology and Immunology, National Defense Medical Center

The Wnt Antagonist SFRPs Family in Hepatocarcinogenesis

20070802

90

20071018

070004

Wen-Ya Huang

Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University

Application of serum of HBV carriers

20070831

20

withdraw

070005

Chi-Ling Chen

Graduate Institute of Clinical Medicine, National Taiwan University

Whole genome approach of HCC patients from multiplex family

20071018

40

20071112

070006

Sen-Yung Hsieh

Liver Research Unit, Chang Gung Memorial Hospital

Conditional onconomics of human hepatoma

20071126

20090115

36

105

20071226

20090205

080007

Hsiao-Fang Sun

Institute of Molecular Medicine, National Cheng Kung University

The Effect of Epstein-Barr Virus Infection on Genomic Alteration and Tumorigenic Susceptibility

20080313

90

20080530

080008

Shiou-Hwei Yeh

Graduate Institute of Microbiology, National Taiwan University College of Medicine

Study of the gender difference in HBV-related HCCs: synergistic carcinogenic effect of HBx and androgen signaling as a mechanism

20080313

80

20080502

080009

Chi-Ying Huang

Institute of Clinical Medicine, National Yang-Ming University

Functional genomics analysis elucidates the signaling networks of Hepatocellular carcinoma

20080415

90

20080526

080010

Ming-Whei Yu

Graduate Institute of Epidemiology, College of Public Health, National Taiwan University

Identification and characterization of candidate genes involved in the pathogenic development of HCC

20080430

40

20080603

080011

Ann-Ping Tsou

Biotechnology and Laboratory Science in Medicine, National Yang-Ming University

Identification of oncomirs that affect HCC metastasis

20080807

80

20080827

080012

Kwang-Huei Lin

Graduate Institute of Biomedical Sciences , Chang Gung University

Functional significance of Dickkopf-4 positively regulated by thyroid hormone receptor in human hepatoma cells

20081020

110

20081104

080013

Chiun Hsu

Department of Oncology, National Taiwan University Hospital

Optimizing Efficacy of Current Anti-angiogenic Therapy for Hepatocellular Carcinoma

20081208

102

20081229

090014

Jian-Wei Chen

Insitute of Biomedical Sciences, National Chung Hsing University

The role of 14-3-3 zeta protein (ywhaz) in regulating epithelial plasticity and lung adenocarcinoma cell metastasis

20090309

24

20090527

090015

Ying-Chin Ko

Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan

Microarray-based copy number and expression profiling in betel related liver cancer

20090319

50

20090504

090016

Chiou-Hwa Yuh

Division of Molecular and Genomic Medicine, National Health Research Institutes

Verify the Genomic and Expression Data of HCC transgenic mouse model in human hepatocellular carcinoma

20090423

102

20090504

090017

Hsiao-Sheng Liu

Microbiology & Immunology, National Cheng Kung University

The role of miR-224 in liver cancer

20090707

25

20090727

090018

Pei-Jer Chen

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine

The assay of tissue sections from disseminated HCC patients by immunohistochemical stain

20090707

10

20090727

090019

Chung-Ming Chang

Division of Molecular and Genomic Medicine, National Health Research Institutes

Examination of HBV spliced RNAs in HBV-related HCC samples

20090730

20

20090821

090020

Shiou-Hwei Yeh

Graduate Institute of Microbiology, National Taiwan University College of Medicine

The Role of MicroRNA Mediated Regulation of Estrogen Receptor Protein in Female Hepatocarcinogenesis

20090730

90

20090821

090021

Sen-Yung Hsieh

Liver Research Unit, Chang Gung Memorial Hospital

Conditional onconomics of human hepatoma

20091023

210

20091112

090022

Wen-Sheng Wu

Department of Medical Technology, Tzu Chi University

Signal transduction in metastasis of hepatocellular carcinoma

20091109

50

Not approved

090023

Shiou-Hwei Yeh

Graduate Institute of Microbiology, National Taiwan University College of Medicine

Vascular Differentiation during Hepatocellular Carcinoma Angiogenesis

20091211

80

20091229

090024

Dar-In Tai

Liver Research Unit, Chang Gung Memorial Hospital

Genetic factors related to hepatitis B virus replication in chronic liver diseases

20091218

100

20091229

100025

Hsiao-Sheng Liu

Microbiology & Immunology, National Cheng Kung University

The role of miR-224 in hepatoma and it’s underlying mechanism

20100111

65

20100208

100026

Yi-Ming Chen

AIDS Research Centre, National Yang-Ming University

A study on the gene regulation and protein-protein interactions of GNMT and use HCC animal model to screen drugs for liver cancer

20100115

30

20100208

100027

Shiu-Feng Huang

Division of Molecular and Genomic Medicine, National Health Research Institutes

Investigation of Carboxypeptidase E splice variant (CPE-deltaN) as a Biomarker of Hepatocellular Carcinoma Metastases/Recurrence

20100205

120

20100309

100028

Li-Tzong Chen

National Institute of Cancer Research, National Health Research Institutes, Taiwan

Study of the Taiwanese cholangiocarcinoma genomics and biomarkers

20100406

32

20100521

100029

Ya-Wen Lin

Department of Microbiology and Immunology, National Defense Medical Center

The Wnt Antagonist SFRPs Family in Hepatocarcinogenesis

20100408

30

20100617

 

100030

Shih-Feng Tsai

Division of molecular & genomic medicine, National Health Research Institutes

Identification of HCC Susceptibility Genes in HBV-Infected Individuals by Genome-wide Association

20100525

400

Not approved

100031

Hsiao-Fang Sun

Institute of Molecular Medicine, National Cheng Kung University

Molecular mechanism of ectopic expression of TIAM2 in the tumorigenesis of Hepatocellular carcinoma

20100713

60

20100824

100032

Sen-Yung Hsieh

Liver Research Unit, Chang Gung Memorial Hospital

Conditional onconomics of human hepatoma

20100813

60

20100913

100033

Hsiao-Sheng Liu

Microbiology & Immunology, National Cheng Kung University

The role of miR-224 in hepatoma and it’s underlying mechanism

20100820

90

20101019

100034

Jang-Yang Chang

National Institute of Cancer Research, National Health Research Institutes, Taiwan

Candidate tumor suppressor genes in HBV-infected hepatocellular carcinoma

20100825

70

20101013

100035

Chuck C.-K. Chao

Biochemistry & Molecular Biology, Chang Gung University

Primary HCC tumor samples for HURP, p53. MDM2 and Gankyrin protein levels (整合型Mechanistic study of potential factors involved in hepatocellular carcinoma子計劃二: Hepatitis B virus X target genes in modulating cell growth/ death during chemotherapy)

20100927

60

20101019

100036

Yi-Ming Chen

AIDS Research Centre, National Yang-Ming University

A study on the subclinical biomarkers in the detoxification pathway for occupational exposure-related hepatocellular carcinoma

20101027

60

Not approved

100037

Shiou-Hwei Yeh

Graduate Institute of Microbiology, National Taiwan University College of Medicine

The Role of MicroRNA Mediated Regulation of Estrogen Receptor Protein in Female Hepatocarcinogenesis

20101119

90

20101206

100038

Ya-Wen Chen

National Institute of Cancer Research, National Health Research Institutes

Characterization of p16 in tumorigenesis and metastasis: focus on mechanisms, detections and regulations

20101217

100

20110103

100039

Jia-Horng Kao

Internal medicine, National Taiwan University hospital

The impact of single nucleotide polymorphism of HLA-DP region on the development of HBV-related hepatocellular carcinoma

20101222

120

20110106

110040

Isao Matsuura

Division of Molecular and Genomic Medicine, National Health Research Institutes

Molecular Characterization of the transforming growth factor beta (TGF-b)-induced protein (TGFBi) expression in HCC

20110103

120

20110119

110041

Mi-Hua Tao

Institute of Biomedical Sciences, Academia Sinica

Generation of mouse models with chimeric human liver for hepatitis virus research

20110307

20

20110407

110042

Chien-Jen Chen

Genomics Research Center, Academia Sinica

Genetic Polymorphisms Associated with Hepatocellular Carcinoma in Chronic Hepatitis B and Hepatitis C Patients

20110309

1050

20110405

110043

Shih-Feng Tsai

Division of molecular & genomic medicine, National Health Research Institutes

Identification of HCC Susceptibility Genes in HBV-Infected Individuals by Genome-wide Association

20110315

120

20110426

110044

Yung-Ming Jeng

Department of Pathology, National Taiwan University Hospital

The analysis of genetic change of viral hepatitis-associated cholangiocarcinoma

20110620

45

20110725

110045

Guann-Yi Yu

Infectious Diseases and Vaccinology, National Health Research Institutes

Hepatitis C Virus- related hepatocellular carcinoma

20110628

20

20110817

110046

Li-Tzong Chen

National Institute of Cancer Research, National Health Research Institutes, Taiwan

Study of the Taiwanese cholangiocarcinoma genomics and biomarkers (continuation of the previous application)

20110628

90

20110817

110047

Hurng-Yi Wang

Graduate Institute of Clinical Medicine, National Taiwan University

Inferring evolutionary history of somatic mutations in hepatocellular carcinoma by phylogeographical approach

20110630

40

20110817

110048

Sen-Yung Hsieh

Liver Research Unit, Chang Gung Memorial Hospital

Identifying novel biomarkers, therapeutic targets and treatments for invasion, early recurrence and metastasis of human hepatoma

20110704

42

20110817

110049

JAW-CHING WU

Institute of Clinical Medicine, National Yang-Ming University

Elucidation of molecular mechanisms of metastasis of hepatocellular carcinoma and clinical implications: emphasis of epithelial-mesenchymal transition and cancer stem cell

20110826

100

20110919

110050

Jia-Horng Kao

Internal medicine, National Taiwan University hospital

The impact of single nucleotide polymorphism of HLA-DP region on the development of HBV-related hepatocellular carcinoma

20110830

120

20111003

110051

Shiou-Hwei Yeh

Graduate Institute of Microbiology, National Taiwan University College of Medicine

The functional role of β-catenin in postnatal liver regeneration and carcinogenesis

20110915

12

20111008

110052

Ya- Huei Huang

Department of Medical Research, Chang Gung Memorial Hospital

Identification and characterization of miRNAs aberrantly express in human hepatocellular carcinomas

20111021

100

20111129

110053

Yu-Ju Chen

Institute of Chemistry, Academia Sinica

Decipher the Altered Membrane Proteome and PTMome in Human Cancer Tissues: A Multiplex Platform for Biomarker Discovery and Validation

20111121

12

20111212

120054

Wei-Chien Huang

Graduate Institute of Cancer Biology, China Medical University

Novel roles of nuclear IKKalpha in tumor progression and metastasis

20120106

60

20120306

120055

Shiou-Hwei Yeh

Graduate Institute of Microbiology, National Taiwan University College of Medicine

Novel agents for hepatocellular carcinoma treatment and revention – targeting phosphatases and kinases

20120112

5

20120118

120056

Wen-Chun Hung

National Institute of Cancer Research, National Health Research Institutes, Taiwan

Role of MECP2 (Methyl CpG-binding protein 2) and PRMT6 (Protein arginine N-methyltransferase 6) in the pathogenesis of human hepatocellular carcinoma

20120123

110

20120315

120057

Sung-Liang Yu

Department of Laboratory Medicine and Medical Biotechnology, National Taiwan University Medical College

Study of a heat shock protein, HLJ1, in etiology for fatty liver

20120223

30

20120321

120058

Sen-Yung Hsieh

Liver Research Unit, Chang Gung Memorial Hospital

Identifying novel biomarkers, therapeutic targets and treatments for invasion, early recurrence and metastasis of human hepatoma

20120330

125

20120423

120059

Jia-Horng Kao

Internal medicine, National Taiwan University hospital

The impact of single nucleotide polymorphism of HLA-DP region on the development of HBV-related hepatocellular carcinoma

20120430

120

20120517

120060

Yi-Ming Chen

AIDS Research Centre, National Yang-Ming University

Identification of novel markers for hepatocellular carcinoma

20120514

240

20120604

120061

Guann-Yi Yu

Infectious Diseases and Vaccinology, National Health Research Institutes

Hepatitis C Virus- related hepatocellular carcinoma

20120619

300

20120717

120062

Pei-Jer Chen

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine

Mapping Genetic Susceptibility Loci in Hepatitis B Virus-related Familial HCCs: A Genome-wide Association Study

20120706

300

20120717

120063

Yan-Hwa Wu

Institute of Biochemistry and Molecular Biology, National Yang-Ming University

Functional Roles of DDX3 on Regulating Cell Stemness and Its Impact on Hepatic Tumorigenesis

20120709

75

20120726

120064

Ching-Yao Yang

Department of Surgery, National Taiwan University hospital

Identification of histone methylation signature and elucidation of their regulation in metastasis and Sorafenib sensitivity of hepatocellular carcinoma (HCC)

20120810

100

20121008

120065

Xiao-hui Lee

Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University,

Probing ROCK I/II activation in liver carcinomas

20120827

80

20120914

120066

Jyh-Lyh Juang

Division of Molecular and Genomic Medicine, National Health Research Institutes

The correlation between alcohol consumption and expression of membrane protein in hepatocellular carcinoma

20120903

40

20121130

120067

Chau-Ting Yeh

Liver Research Center, Chang-Gung Memorial Hospital

Detection of HBV surface gene truncation mutations in HCC patients

20121009

400

20121121

120068

Chi-Ying Huang

Institute of Biiopharmaceutical Sciences, National Yang-Ming University

(1) Characterization of alternatively spliced   genes in human Hepatocellular Carcinoma

(2) Using HCC tissue microarray to validate   predicted biomarkers

20121012

90

20121121

120069

Chi-Ling Chen

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University

The construction and validation of a predictive model of survival after diagnosis of hepatocellular carcinoma in Taiwan

20121023

5050

20121209

120070

Hui-Ching Wang

Institute of Molecular and Cellular Biology, National Tsing Hua University

Investigate the expression of Sgo1, HIF1α and FoxM1 in HBV-related liver and HCC

20121203

20

20121220

120071

Ih-Jen Su

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes

The significance of viral oncoproteins and immune response in the prognosis of hepatocellular carcinoma in chronic hepatitis B patients receiving hepatectomy

20121224

200

20130118

130072

Chien-Jen Chen

Genomics Research Center, Academia Sinica

Genetic Polymorphisms Associated with Hepatocellular Carcinoma in Chronic Hepatitis B and Hepatitis C Patients

20130227

90

20130312

130073

Jia-Horng Kao

Hepatitis Research Center, National Taiwan University Hospital

The impact of single nucleotide polymorphisms of HLA-DP region on the development of HBV-related hepatocellular carcinoma

20130417

170

20130503

130074

Ta-Sen Yeh

Surgery, Chang Gung Memorial Hospital

Biosignature of hepatocellular carcinoma and cholangiocarcinoma

20130513

200

20130604

130075

Shih-Feng Tsai

Division of molecular & genomic medicine, National Health Research Institutes

Recurrent Somatic Mutations in Loss of Heterozygosity Regions of Hepatocellular Carcinoma

20130528

250

20130618

130076

Kwang-Huei Lin

Graduate Institute of Biomedical Sciences , Chang Gung University

What is the role of thyroid hormone receptors during oncogenesis?

20130531

160

20130618

130077

Pei-Jer Chen

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine

Mapping Genetic Susceptibility Loci in Hepatitis B Virus-related Familial HCCs: An exome-capture sequencing Study

20130823

37

20130911

130078

Jeng-Jiann Chiu

Institute of Cellular and System Medicine, National Health Research Institutes

Endothelial Progenitors Promote Hepatocarcinoma Intrahepatic Metastasis through Monocyte Chemotactic Protein-1 Induction of MicroRNA-21

20131007

15

20131028

130079

Ching-Yao Yang

Department of Surgery, National Taiwan University hospital

Identification of histone methylation signature and elucidation of their regulation in metastasis and Sorafenib sensitivity of hepatocellular carcinoma (HCC)

20131007

100

20131028

130080

Yi-Ming Chen

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University

Characterization of DEPDC6 and its Interactions with GNMT in the Pathogenesis of Hepatocellular Carcinoma

20131007

60

20131028

130081

Ping-Hui Tseng

Institute of Biochemistry and Molecular Biology, National Yang-Ming University

The roles of Toll-like receptors in hepatocellular carcinoma

20131104

30

20131125

130082

Jen-Liang Su

National Institute of Cancer Research, National Health Research Institutes, Taiwan

The expression level of Dicer is associated with sorafenib resistance in liver cancer

20131113

100

20140106

130083

Tsung-Hsien Chuang

Immunology Research Center, National Health Research Institutes

Molecular target in arginine metabolic pathway for cancer therapy

20131120

330

20131225

140084

Li-Tzong Chen

National Institute of Cancer Research, National Health Research Institutes, Taiwan

Study of the Taiwanese cholangiocarcinoma genomics and biomarkers (continuation of a previous application in 2011)

20140116

27

20140205

140085

Ann-Lii Cheng

Department of Oncology, National Taiwan University Hospital

The role of antiviral therapy in preventing early recurrence of hepatitis virus B related hepatocellular carcinoma after curative resection

20140603

60

20140630

140086

Chau-Ting Yeh

Liver Research Center, Chang-Gung Memorial Hospital

Detection of HBV surface gene truncation mutations in HCC patients

20140609

200

20140630

140087

Chien-Jen Chen

Genomics Research Center, Academia Sinica

Single Nucleotide Polymorphisms Associated with Hepatocellular Carcinoma Among Chronic Hepatitis B and Hepatitis C Patients

20140617

2000

20140707

140088

Chun-Jen Liu

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine

Association of IL28B genotypes with the clinical outcomes of patients with dual chronic hepatitis B and C: A comparison among HBV/HCV dual infection, HBV mono-infection and HCV mono-infection

20140618

700

20140707

140089

Sen-Yung Hsieh

Liver Research Unit, Chang Gung Memorial Hospital

The roles and oncogenic mechanisms of RET-finger protein/TRIM27 in human hepatocellular carcinoma

20140619

50

20140707

140090

Hsiao-Fang Sun

Institute of Molecular Medicine, National Cheng Kung University

Genome Reprogramming in Cancer Cell

20140619

70

20140707

140091

Yi-Hsiang Liu

Department of Pathology, Chang Bing Show Chwan Memorial Hospital

Investigate roles of the modulation of cytoskeletons and their associated proteins playing in the tumor biology of human hepatocellular carcinoma

20140710

90

20140820

140092

Lin-Tsing Chen

Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital

Tumor Biology of Hepatocellular Carcinoma

20140919

90

20141106

140093

Yoa-Pu Hu

Department of Pharmacy, National Defense Medical Center

Function and expression of drug transporters dictate the different rosuvastatin systemic exposure between Asians and Caucasians

20140924

40

20141013

140094

Su-Fang Lin

National Institute of Cancer Research, National Health Research Institutes, Taiwan

FGFR2 gene fusion in Taiwanese intrahepatic cholangiocarcinoma tissues

20141208

90

20150106

150095

Wei-Lun Tsai

Division of Gastroenterology, Kaohsiung Veterans General Hospital

Identification of novel therapeutic targets in HCV related hepatocellular carcinoma using next generation sequencing

20150112

200

20150224

150096

I-Cheng Lee

Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital

The Role Of Host Immune Regulators in the Prognosis of Hepatocellular Carcinoma

20150410

150

20150428

150097

Yun-Ru Liu

Joint Biobank, Taipei Medical University

The association analysis of a histone mRNA as a new biomarker of HCC recurrence

20150605

92

20150625

150098

Dar-In Tai

Gastroenterology and hepatology, Chang Gung Memorial Hospital

Human genetic polymorphism in therapeutic response of chronic hepatitis B

20150610

1000

20150707

150099

Yi-Hsiang Liu

Chiung-Chi Cheng

Chang Bing Show Chwan Memorial Hospital

Differential expression of the cytoskeleton proteins and the plectin in human hepatocellular carcinoma versus liver cells and in cholangicarcinoma versus bile duct epithelium

20150618

120

20150724

150100

Sen-Yung Hsieh

Chang Gung Memorial Hospital

In vivo functional genomics to decipher the genes/mechanisms orchestrating hepatoma invasion

20150710

180

20150803



150101

Hsu Shih-Hsien

KMU

To explore the regulatory effect of aryl hydrocarbon receptor (AhR) on initiation and enhance role of oncoprotein ISX in human hepatocellular carcinoma (HCC)

20150805

200

20150901

150102

Pei-Jer Chen

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine

Development of new treatment and biomarker for hepatocellular carcinoma: from woodchuck to human (3/3)

20150826

120

20150916

150103

Wan-long Chuang

 

Kaohsiung Medical University

Chung-Ho Memorial Hospital

HCV infection affects on growth hormone signaling pathway in liver diseases and hepatocellular carcinoma progression

20150908

200

20151028

150104

Yi-Hsiang Huang

Taipei Veterans General Hospital

Division of Gastroenterology, Department of Medicine

The Role of Tid1 Expression in Behavior and Prognosis of hepatocellular Carcinoma

20150926

200

20151109

150105

Chiun Hsu

National Taiwan University Hospital

Incorporation of genomic and immunological studies for biomarker identification for hepatocellular carcinoma

20151101

600

20151126

150106

Yuh-Shan Jou

Institute of Biomedical Sciences ,Academia Sinica

Dissecting molecular mechanisms of PSPC1 overexpression driven cancer EMT, stemness and tumor metastasis.

20151230

200

20160118

150107

Pei-Jer Chen

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine

Development of new treatment and biomarker for hepatocellular carcinoma: from woodchuck to human (3/3)

20151230

120

20160110



160108

Jui-Hsiang Hung

Department of Biotechnology, Chia Nan University of Pharmacy and Science

To investigate the effect of nucleobindin-2 overexpression by endoplasmic reticulum stress on hepatocellular carcinoma treatment

20160219

120

20160321

160109

Kwang-Huei Lin

Graduate Institutes of Biomedical Sciences, Chang Gung University

Characterization the physiological significance of angiogenesis associated gene regulated thyroid hormone

20160322

160

20160418

160110

Shih-Feng Tsai

Institute of Molecular and Genomic Medicine, National Health Research Institutes

Translational research on genomic variations in liver cancer

20160328

250

20160411

160111

I-Cheng Lee

Division of Gastroenterology and Hepatology, Department of Medicine ,Taipei Veterans General Hospital

The Role of Host Immune Regulators and Tumor Microenvironment in the Prognosis of Hepatocellular Carcinoma

20160411

200

20160615

160112

Alice L. Yu

Institute of Stem Cell and Translational Cancer Research, Linkou Chang Gung Memorial Hospital

Tumor Biology of Hepatocellular carcinoma

20160503

90

20160524

160113

Yu-Tsung Shih

Institute of Cellular and System medicine, National Health Research Institutes

Unrevealing the Metabolic Abnormalities of Endothelial Cells in Response to the Angiogenic Niche Composed by Endothelial Progenitors and Hepatocarcinoma Cells

20160524

24

20160627

160114

Shiou-Hwei Yeh

Dept. of Microbiology, College of Medicine, National Taiwan University

The distribution trend of Glypican-3 expression in hepatocellular carcinoma

20160817

120

20160906

160115

Li Ching Li

Shuang Ho Hospital, Taipei Medical University

Investigation of nicotine/cigarette-smoke promotes metastasis of hepatocellular carcinoma through nAChR and pre-clinically evaluation of correlation between smoking and hepatocellular carcinoma

20161011

180

20161128

160116

Chiun Hsu

National Taiwan University Hospital

Incorporation of genomic and immunological studies for biomarker identification for hepatocellular carcinoma

20161026

800

20161128

160117

Hsieh, Shie-Liang

Genomics Research Center, Academia Sinica

Liver and plasma C-type lectin 18 (CLEC18) expression in hepatitis B and C virus infected patients

20161122

260

20170209

160118

Yan-Hwa Wu Lee

Department of Biological Science and Technology, National Chiao-Tung University

Functional roles of DDX3 in regulating exosome biogenesis and its therapeutic potential on hepatic tumorigenesis

20161214

75

20170811

170119

Yi-mimg Chen

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University

A study of the epigenetic regulation of GNMT gene expression and the role GNMT plays in the control of global DNA methylation

20170127

80

20170209

170120

Pei-Jer Chen

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University

Taiwan Research Biosignature Network on Patients at High Risk of Hepatocellular Carcinoma (TARGET-HCC)

20170213

90

20170419

170121

Hsien-Chung Yu

Division of Gastroenterology and Hepatobiliary, Department of Internal Medicine, Kaohsiung Veterans General Hospital

The correlation between serum BioFibroScore, Pre-S Deletion and Histological Fibrosis in Chronic Hepatitis B Patients with Hepatocellular Carcinoma Receiving Curative Resection

20170214

150

20170419

170122

Tung-Hung Su

Internal Medicine, National Taiwan University Hospital

Clinical implications of immunophenotypes in liver fibrosis and hepatocellular carcinoma

20170301

150

20170612

170123

Chia-Hung Yen

Graduate Institute of Natural Products, Kaohsiung Medical University

A study of the role of redox state in the development of sarcomatoid hepatocellular carcinoma and its application in anti-liver cancer drug discovery.

20170519

120

20171020

170124

Chau-Ting Yeh

Liver Research Center, Chang-Gung Memorial Hospital

Clinical and molecular characterization of hepatocellular carcinoma carrying distinct patterns of HBV S gene truncation mutations

20170324

11

20170612

170125

Chau-Ting Yeh

Liver Research Center, Chang-Gung Memorial Hospital

Clinical and molecular characterization of hepatocellular carcinoma carrying distinct patterns of HBV S gene truncation mutations

20170624

200

20170811

170126

Jun-Yang Liou

Institute of Cellular and System Medicine, National Health Research Institutes

To investigate the role of AKR1B10 expression and metabolism in regulating epithelial-mesenchymal transition and drug resistance of hepatocellular carcinoma

20170928

150

20171222

170127

Li-Fen Shen

Drug Development Division, TaiRx, Inc.

A Pilot Study of Tumor Prognostic Biomarker in Hepatocellular Carcinoma

20171212

140

20180205

170128

Jun-Yang Liou

Institute of Cellular and System Medicine, National Health Research Institutes

To investigate the role of AKR1B10 expression and metabolism in regulating epithelial-mesenchymal transition and drug resistance of hepatocellular carcinoma

20171228

150

20180205

180129

Yue-Liang Guo

National Institute of Environmental Health Sciences, National Health Research Institute

Air pollutants and hepatocellular carcinoma survival

20180131

1000

20180927

180130

Jyh-Lyh Juang

Institute of Molecular and Genomic Medicine, National Health Research Institutes

Identification of potential mechanism for liver cancer in tumor tissue

20180207

40

20180409

180131

Mei-Hwei Chang

Pediatrics, National Taiwan University College of Medicine

Long-term Follow-up of Chronic Hepatitis B Virus Infection from Mother-to-Infant Transmission to Adult Life

20180319

50

20180409

180132

Jinn-Moon Yang

Institute of Bioinformatics and System Biology, National Chiao Tung University

Intelligent Computing Precision Medical and Drug Development Platform – Integrated dynamic systems biology models to study the mechanisms between diabetes mellitus and liver cancer for developing biomarkers and drugs

20180321

120

20180409

180133

Jui-Hsiang Hung

Department of Biotechnology, Chia Nan University of Pharmacy and Science

To investigate the mechanism of endoplasmic reticulum stress-induced nucleobindin-2 expression and its effect on the treatment of liver cancer

20180322

120

  20180626

180134

Yan-Hwa Wu Lee

Department of Biological Science and Technology, National Chiao Tung University

Center for Intelligent Drug Systems and Smart Bio-devices, IDS2B

20180330

30

20180409

180135

Pei-Jer Chen

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University

Taiwan Research Biosignature Network on Patients at High Risk of Hepatocellular Carcinoma (TARGET-HCC)

20180427

50

  20180626

180136

Kun-Chih Tsai

National Institute of Cancer

Research, National Health Research Institutes

The role of ASPM-Wnt signaling in hepatoma cancer stemness and progression and the development of the related nano- and gene therapy

20180821

70

Overdue

180137

Jyh-Lyh Juang

Institute of Molecular and Genomic Medicine, National Health Research Institutes

Identification of potential mechanism for liver cancer in tumor tissue

20181003

40

20181220

180138

Mei-Hwei Chang

Pediatrics, National Taiwan University College of Medicine

Long-term Follow-up of Chronic Hepatitis B Virus Infection from Mother-to-Infant Transmission to Adult Life

20181005

150

20181220

180139

Tzu-Ling Tseng

Bio Preventive Medicine Corp.

Cancer biomarkers development

20181012

60

20190227

180140

Chi-Ying Huang

Institute of Biopharmaceutical Sciences, National Yang-Ming University

The prognostic correlation of exosomal GPC3 level at diagnosis, surveillance and survival of patients with hepatocellular carcinoma

20181105

50

20190227

180141

Wen-Lung Ma

Graduate Institute of BioMedical Sciences, China medical university

Study of the metabolic syndrome-related VLDL and VLDLR roles in hepatocellular carcinoma

20181112

225

20181220

190142

Chao-Wei Hsu

Division of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital

Clinical and Functional Significance of Infections of Genetically Different Hepatitis Delta Virus

20190108

300

20190227

190143

Mei-Hwei Chang

Pediatrics, National Taiwan University College of Medicine

Long-term Follow-up of Chronic Hepatitis B Virus Infection from Mother-to-Infant Transmission to Adult Life

20190111

100

20190227

190144

Yan-Hwa Wu Lee

Department of Biological Science and Technology, National Chiao Tung University

Center for Intelligent Drug Systems and Smart Bio-devices, IDS2B

20190314

50

20190424

190145

Ting-Fen Tsai

Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University

Development of novel therapeutics for non-alcoholic fatty liver diseases (NAFLD) and steatohepatitis (NASH)

20190322

260

20190820

190146

Shih-Feng Tsai

Institute of Molecular and Genomic Medicine, National Health Research Institutes

Translational research on genomic variations in liver cancer

20190327

150

20190424

190147

Ling-Yueh Hu

Laboratory of Translational Medicine Office, Development Center for Biotechnology

Explore the expression and distribution of the immune checkpoint related proteins in normal liver tissue

20190517

40

20190625

190148

George Wei

Clinical Project Management Dep. ACT Genomics Co., Ltd.

To Study the Association between Mutational Spectrum/Tumor Microenvironment and Prognosis in HCC/CC Using Archived Specimens

20190520

300

20190625

190149

Yang-Hsiang Lin

Liver Research Center, Chang Gung Memorial Hospital, Linkou

Characterization of LOC731656 functions in human hepatocellular carcinoma and its clinical significance

20190702

80

20190820

190150

Lee, Mei-Hsuan

Institute of Clinical Medicine, National Yang Ming University

DNA methylation profiling, antigen representation of HLA and associated risk for hepatocellular carcinoma

20190815

900

20191007

190151

Sen-Yung Hsieh

Dept. of Gastroenterology & Hepatology, Linkou Chang Gung Memorial Hospital

Decipher genomic and epigenomic alternations in the liver and digestive cancers

20190909

108

20191007

190152

Oliver Yoa-Pu Hu

Collage of Pharmacy, Taipei Medical University

Study of drug metabolism in homogenized liver

20191015

10

Overdue

190153

Yan-Hwa Wu Lee

Department of Biological Science and Technology, National Chiao Tung University

Center for Intelligent Drug Systems and Smart Bio-devices, IDS2B

20191015

30

20191213

190154

JAW-CHING WU

Institute of Clinical Medicine, National Yang Ming University

Investigating the regulatory mechanism of glycosphingolipids in Hepatitis B virus-transgenic mice and human liver cancer specimens for the development of novel diagnostic and therapeutic strategies for Hepatocellular carcinoma

20191115

680

20200213

190155

Sheng-Hui Lan

Department of Life Sciences

and Institute of Genome Sciences, National Yang-Ming University

Physiologic and pathologic roles of FUS for microRNA turnover by selective autophagy

20191129

16

20200213

200156

Jun-Yang Liou

Institute of Cellular and System Medicine, National Health Research Institutes

Characterization of HIOMT isoform for 5-MTP biosynthesis and its defect in cancer

20200225

150

20200422

200157

Chao-Wei Hsu

Division of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital

Clinical and Functional Significance of Infections of Genetically Different Hepatitis Delta Virus

20200323

8

20200422

200158

Chen, Shao-Yuan

Laboratory of Translational Medicine Office, Development Center for Biotechnology

Explore the impact of signal transduction factors in tumor progression

20020417

90

20200714

200159

Pei-Ing Hwang

Digital Health Planning Group, Development Center for Biotechnology

Development of Biomarkers for Precision Medicine with Big Data Analyses

20200602

50

20200812

200160

Cheng-Yi Chen

Department of Cell Biology and Anatomy, National Cheng Kung University

Investigate the molecular mechanism of protein tyrosine phosphatase IVA3 (PTP4A3) in cisplatin/doxorubicin chemoresistance of hepatocellular carcinoma

20200616

160

20200812

200161

Yan-Hwa Wu Lee

Department of Biological Science and Technology, National Chiao Tung University

Center for Intelligent Drug Systems and Smart Bio-devices, IDS2B

20200827

50

20200921

200162

Shun-Fa Yang

Department of Medical Research, Chung Shan Medical University Hospital

Study of the LncRNA genetic variants in hepatocellular carcinoma

20200309

400

20200422

200163

Ho Ming-Chih

Surgery, National Taiwan University Hospital

Specific HBV-human chimera DNA as a novel biomarker for predicting the outcome of HCC after transplantation (2)

20200409

34

20200520

200164

Chao-Cheng Huang

Pathology, Kaoshiung Chang Gung Memorial Hospital

Investigating the Role of Delta-like 1 Homolog (DLK1) in T Cell Immune Surveillance of Hepatocellular Carcinoma

20200408

80

20200520

200165

Kuo-Shyang Jeng

General Surgery, Far Eastern Memorial Hospital

To investigate the role of inhibition of sonic Hedgehog signaling pathway in increasing the sensitivity of doxorubicin in hepatocellular carcinoma-an in vitro and in vivo study

20200413

20

20200520

200166

Lin Ming-Tsung

Division of Hepato-Gastroenterology, Kaohsiung Chang Gung Memorial Hospital

Biomarkers analysis for hepatocellular carcinoma and liver fibrosis

20200408

20

20200520

200167

Kelvin Kun-chih Tsai

Graduate institute of Clinical Medicine, Taipei Medical University

The role of ASPM-Wnt signaling in hepatoma cancer stemness and

progression and the development of the related nano- and gene-therapy

20200416

90

20200610

200168

Chen Yaw-Sen

Department of Surgery, E-Da  Hospital

To study amino-acid-dependent GATORC1/mTORC1 signaling in the development of hepatocellular carcinoma

20200423

90

20200610

200169

Hsieh, Ching-Hua

Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital

Using circulating biomarkers to identify the patients with hepatocellular carcinoma-based on the samples from National Biobank Consortium of Taiwan

20200414

50

20200714

200170

Chih-Yang Huang

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

Study the genes and molecular mechanisms affecting of colorectal cancer, lung cancer and liver cancer

20200512

23

20200812

200171

Wen-Chi, Yang

Hematology and medical oncology, E-Da hospital

Immune landmark in local limited HCC and advanced HCC

20200422

120

20200921

200172

Jyh-Lyh Juang

Institute of Molecular and Genomic Medicine, National Health Research Institutes

Indentification of potential mechanism for liver cancer in tumor tissue

20200922

48

20201028

200173

Zhong-Zhe Lin

Medical Oncology, National Taiwan University Cancer Center

Define the clinicopathologic significance of CpG island methylator phenotype in intrahepatic cholangiocarcinoma

20201111

100

20201127

210174

Andrew Yueh

Institute of biotechnology and pharmaceutical research, National Health Research Institute

Development of next-generation biologics for cancer & immunotherapy therapy

Item 1. Development of next-generation antibody drug conjugates

20210114

40

20210222

210175

Yi-Ming Arthur Chen

Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University

Using TLCN unlink samples to evaluate the application of novel circulating microRNAs on hepatocellular carcinoma diagnostic and prognostic

20210412

100

20210625

210176

Ruey-Hwa Chen

Institute of Biomedical Science, Academia Sinica

The roles of long noncoding RNA LINAT in tumor progression

20210930

100

20211007

210177

Kwang-Huei Lin

Graduate Institutes of Biomedical Sciences, Chang-Gung University

The clinical significance of thyroid hormone-regulated non-coding RNAs

20211027

120

20211217

220178

Yi-Hsin Yang

Institute of cancer research,  National Health Research Institute

Investigate metabolic complications in liver cancer patients treated with target therapies

20220117

6000

20220223

220179

Yi-Wen Huang

CRC, Taipei Medical University Hospital

To explore the difference in molecular signature between virus and steatosis-related liver cancer

20220510

1050

20220718

220180

Mei-Hsuan Lee

Institute of Clinical Medicine, National Yang Ming Chiao Tung University

Genetic susceptibility and the associated risk of cholangiocarcinoma and non-hepatitis B and non-hepatitis C hepatocellular carcinoma

20220617

300

20220718

220181

Tsai-Yuan Hsieh

Division of Gastroenterology, Tri-Service General Hospital

To investigate the regulatory mechanisms of CRNDE gene in hepatocellular carcinoma and the clinical significance of its associated molecular expression

20220717

50

20220831

220182

Shu-Chi Wang

Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University

Investigation of exosomal DANCR in predicting of HCC recurrence in HCV-related HCC post curative therapy, mechanism of action, and the feasibility on precision medicine application.

20220812

200

20220831

220183

Shao-Chun Wang

College of Medicine, China Medical University & Hospital

Developing novel tumor and blood biomarkers of marker-guided effective cancer therapies

20220726

108

20220831

220184

Chao-Wei Hsu

Department of Hepatology and Gastroenterology, Chang Gung Memorial Hospital

Analyses of Hepatitis Delta Virus Mutants Isolated from Hepatocellular Carcinoma Patients Co-infected with Hepatitis B/D Viruses

20220815

4

20220831

220185

Hsin-Ling Hsu

Institute of Molecular and Genomic Medicine, National Health Research Institutes

Roles of microRNA-34a and MCT-1 in lipid metabolism during macrophage reprogramming and carcinogenesis

20220926

28

20230316

220186

Donching Lee

TAQKEY Science Co., Ltd.

DNA methylation for hepatocellular carcinoma

20221008

15

20230107

220187

Pei-Jer Chen

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine

Contribution of HDV in HBV-induced insertional mutagenesis in HBV, HDV-related HCC

20221014

70

20221216

220188

Cherng Yih-Giun

Superintendent Office, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare

Identification of Targetable mediators involving in PP1R15B Pathway to Overcome Resistance to Lenvatinib in Drug-Tolerant Persister Liver Cancer

20221109

30

20230321

220189

Chau-Ting Yeh

School of medicine, Chang-Gung University

Analysis of the role of ApoC1 in hepatocarcinogenesis

20221115

200

20221216

220190

Jo Ting Tsai

Radiation Oncology, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare

A Mechanism Study of the Interplay between pre-mRNA-SRSF1 and XIRP2 in Radiation Resistance and Metastasis of Hepatocellular Carcinoma

20221118

30

20230328

220191

Hui-Lin Wu

Hepatitis Research Center, National Taiwan University Hospital

Study on the early recurrence of HBV-associated hepatocellular carcinoma: with emphasis on the molecular mechanisms and clinical implications of a novel metastatic tumor antigen 1 spliced variant, MTA1dE4

20221227

150

20230222

230192

En-Chi Hsu

Institute of Molecular and Genomic Medicine, National Health Research Institutes

Develop Liquid Biopsy-Based Exosomal Correlative Signature Utilizing Oncoprotein-microRNA-circRNA Functional Networks for Early Detection of Liver Cancer

20230105

150

20230406

230193

Chao-Wei Hsu

Department of Hepatology and Gastroenterology, Chang Gung Memorial Hospital

Analyses of Hepatitis Delta Virus Mutants Isolated from Hepatocellular Carcinoma Patients Co-infected with Hepatitis B/D Viruses

20230109

70

20230222

230194

Jer-Wei Chang

Precision Medicine and Informatics, Institute Drug Evaluation Platform, Development Center for Biotechnology

Development of Different Cancers Biomarkers for Precision Medicine with Big Data Analyses

20230203

15

20230628

230195

Tang- Yuan Chu

Department of Obstetric & Gynecology, Tzu Chi Hospital, Hualien

FE25 cell transformation as a serum bioassay to detect cancers and estimate tumor load: a validation study and characterization of the transformation activity

20230602

32

20230822

230196

Hung-Chih Yang

Graduate Institute of Microbiology, NTUCM

Comprehensive Delineation of Oncofetal Ecosystem in Hepatocellular Carcinoma after Hepatectomy

20230620

270

20230822

230197

Wen-Hui Su

Department of Biomedical Sciences, Chang Gung University

Feasibility Assessment of Polygenic Risk Score-Stratified Screening in Hepatocellular Carcinoma.

20230911

600

20231026

230198

Kun-Yu Lai

Department of Optics and Photonics, National Central University

High throughput Raman spectroscopy: A new DNA testing for cancers and cord blood

20231026

10

20231213

240199 Hui-Lin Wu Hepatitis Research Center, National Taiwan University Hospital Investigating the roles and molecular mechanisms of the major vault protein (MVP) in hepatocellular carcinoma induced by HBV (hepatitis B virus) and HBV with concurrent metabolic dysfunction-associated steatotic liver disease (MASLD)

20240326

200

20240418

240200 Tung-Hung Su Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital Clinical utility of laminin γ2 monomer (LG2m) in prognosing extrahepatic spread (EHS) of tumor in early to intermediate stage hepatocellular carcinoma (HCC) patients

20240327

240

20240418

240201 Ming-Shiu Hung Institute of Biotechnology & Pharmaceutical Research, National Health Research Institutes Orphan G protein-coupled receptor in the pathogenesis of liver fibrosis

20240419

15

20240614

240202 Chau Ting Yeh Gastroenterology,Hepatobiliary and Biology, Chang Gung Memorial Hospital,Linkou Genetic and virological factors in the cirrhotic liver in association with hepatocellular carcinoma postoperative prognosis

20240522

30

20240614

240203 Shiou-Hwei Yeh Graduate Institute of Microbiology, National Taiwan University College of Medicine New immunotherapies for chronic hepatitis B and hepatocellular carcinoma — Subproject 4: Driver mutations in HBV-infected hepatocytes enabling immune-escape and tumorigenesis: mechanisms and therapeutic targets

20240620

185

20240813

240204 Kuo-Sheng Liao Department of Pathology, Taoyuan General Hospital, Ministry of Health and Welfare The role of protein phosphatase deficiency in liver cell junction defects and cancers

20240704

80

20240813

240205 Ming-Hui Lin Department of Gastroenterology, Taoyuan General Hospital, Ministry of Health and Welfare Establishing a zebrafish model to study the molecular mechanisms of NASH and NASH associated HCC toward develop therapies

20240718

150

20240813

240206 YU-SHAN WANG General Manager Office,UniPharma Co.,Ltd. Analysis of the differential expression of the DR-70 tumor marker in various cancer patients compared to a healthy population, utilizing serum samples from the National Biobank Consortium of Taiwan

20240712

114

20240813

240207 Mei-Hsuan Lee Institute of Clinical Medicine, National Yang Ming Chiao Tung University Identifying Protein Biomarkers for Early Detection of Hepatobiliary Cancers

20240730

400

20241022

240208 Ming-Wei Lai Pediatric,Linkou Chang Gung Memorial Hospital Investigating Extracellular Vesicles and Their Role in Hepatitis B Virus-Related Liver Disease Progression

20240815

40

20241022

240209 Ming-Wei Lai Pediatric,Linkou Chang Gung Memorial Hospital Identification and characterization of novel biomarkers of response to targeted therapy in patients with advanced HBV-related hepatocellular carcinoma

20240820

40

20241022

240210 Wey-Ran Lin Gastroenterology, Linkou Chang Gung Memorial Hospital To identify the potential biomarkers in advanced hepatocellular carcinoma: using circulating and exosomal mitochondrial DNA and their mutations

20240815

40

20241023

240211 Ya-Hsuan Chang Institute of Molecular and Genomic Medicine, National Health Research Institute Derivation and validation of prognostic prediction models in patients with intermediate and advanced hepatocellular carcinoma based on GALNT14 genotype

20240903

4000

20241022

240212 Kuan-Fu, Liao Department of Internal Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Explore the biological function of LITAF in hepatocellular carcinoma proliferation and metastasis

20241018

15

Under Review

240213 Zhong-Zhe Lin Medical Oncology, National Taiwan University Cancer Center Define the clinicopathologic significance of CpG island methylator phenotype in intrahepatic cholangiocarcinoma

20241031

132

Under Review

240214 Shih-Hsien Hsu Graduate Institute of Medicine, Kaohsiung Medical University Exploring the potential impact of genomic mutation of homeobox gene-ISX in hepatocellular carcinoma (HCC) pathogenically and therapeutically

20241118

100

Under Review

Announcement day:2024/12/29

Comments are closed.